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Product Description
It is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies of synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of gene products? Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods. Leading experts in the best understood brain regions bring together the molecular, anatomical, functional, and behavioral data in authoritative integrated accounts. The chapters are organized in the same format, covering the neural elements, synaptic connections, basic circuits, physiology, neurotransmitters, neuromodulators, membrane properties, dendritic properties, and with a final section on how the circuits mediate specific behaviors. The uniform framework for each chapter enables the authors to higlight the principles that are common to all regions, as well as the adaptations unique to each, thus serving as a model for understanding the neural basis of behavior.
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Average Customer Review:
0 of 2 people found the following review helpful:
Comprehensive book on neuroscience/cortical networks, 2007-05-14
This book provides a great understanding of the basic elements of brain and their interactions. It takes a radical approach of synaptic organization as the basis of brain functions. It is a must for everyone interested in neuro/brain/mind science.
7 of 7 people found the following review helpful:
 A classic work now in its 5th edition, 2005-11-05
I became acquainted with this book when I read the first edition, way back in the late 70s when I was a neuroscience grad student. I remember how impressed I was that here, for the first time really, different areas of the brain could be analyzed and compared by how the neurons wired up with each other. Later in life as a young neurologist I read through the 3rd edition, and now as a more seasoned one I've just finished reading the fifth. The book has maintained its basic organizational structure while greatly expanding its content, sometimes to the detriment of clarity being lost in the details, which is why I took off a star. The first two chapters are very helpful, with one of the best discussions of different ion channels and neurotransmitter receptors in the context of neural cell physiology I've seen. In subsequent chapters the basic circuitry of the spinal cord, cochlear nucleus, olfactory bulb, retina, cerebellum, thalamus, basal ganglia, olfactory cortex, hippocampus and cerebral cortex are discussed in similar fashion. First the neuronal elements--cell types--are defined, then the basic anatomy of the area, then the synaptic connections between different types of neurons, then the anatomy of the circuitry, then the physiology of the synaptic actions. Finally an attempt is made to relate all of these basics to how the brain area functions for the organism.
As others have pointed out, the book requires concentration to read, even to somebody with my long background. But it is rewarding to see how far the field has come in the nearly 30 years I've been studying it. It's only marginally clinically relevant for a neurologist, but for basic neuroscientists I'd consider it a must read.
2 of 4 people found the following review helpful:
The Synaptic View of Brain Function, 2004-06-11
This is a very good neurophysiology book from the morphological and physiological viewpoints. It's inexpensive and well written. Thanks Gordon.
7 of 8 people found the following review helpful:
Marvelous book for the brain aficionado ..., 2004-03-17
This is an excellent book: clear, well-organized, and well-written. It examines how groups of neurons give rise to brain functions. The introductory chapter lays the groundwork, going over basic theories of how groups of cells perform computations and what mechanisms they use to do it. Subsequent chapters stand alone, each with a focus on a particular brain region (hippocampus, basal ganglia, cortex, thalamus, retina, etc.).I agree with an earlier reviewer: this book is not for the uninitiated, although it is spectacularly helpful for theoretical neuroscientists who are modeling cell assemblies as well as experimentalists working at the cell or systems level. However, I disagree with his list of good introductory books. "Principles of Neural Science" in particular is a good reference but not terribly readable. I would recommend Nicholls' "From Neuron to Brain" as a more accessible book about brain function. The Scientific American series, including "The Scientific American Book of the Brain," is quite good factually and provides a more general overview including some psychology, but the quality of the writing varies. Finally, for kicks, a newcomer should try the enjoyable, controversial "How the Mind Works" by Stephen Pinker. He is biased and arrogant, but also clever and entertaining.
2 of 13 people found the following review helpful:
^^*, 2001-09-08
my brain study group used this book for textbook. my major is traditional chinese medicine treatment of neurology disease, so i need some neuroscience part. this book is not easy reading, but this book gaved me many information for neuroscience.
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