by Bertil Hille
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Product Description
This fully revised and expanded third edition of "Ionic Channels of Excitable Membranes" describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signalling, structural biology, and molecular biology and genomics. The text begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. It is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses.
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Average Customer Review:
0 of 0 people found the following review helpful:
 for the brain child, 2008-10-03
I got this book for a class and never used actually used it. The book is really hard to understand and over the top. Be warned if you don't have a strong background in biophysics and other sciences this book will make no sense.
1 of 1 people found the following review helpful:
 The bane of my spring semester, 2008-07-03
Although this book is very thorough when it comes to 'ion channels of excitable membranes,' it's essentially a 1000-page literature review. That's fine if you're an expert in the field (i.e. college professor), but for an undergraduate, it contained an overwhelming amount of information, including calculus-based math. Sometimes, it was helpful to consult when my class notes were incomplete. Otherwise, reading the assigned chapters in this book proved a waste of time.
0 of 0 people found the following review helpful:
 Excellent and useful text., 2006-11-17
This text is an encyclopedia of information from kinetics to structure to interactions. It's got a reserved space on my academic bookshelf.
7 of 13 people found the following review helpful:
Destined to become an Oprah Book Club selection, 2005-12-08
Some books have opening sentences that grab you in an instant. "Call me Ishmael." "It was the best of times, it was the worst of times." And now, Hille joins the list of authors to reach out and grab us, with the awe-inspiring "Ion channels are macromolecular pores in cell membranes."
Even after my fifth reading, that line still gives me the shivers.
But it takes more than a brilliant opening to make a great book, and Hille delivers. From a distinctly jaunty derivation of the Nernst equation to the page-turning thrills of non-stationary fluctuation analysis, the book is hard to put down. It does bog down a little in Chapter 10, "Elementary Properties of Ions in Solution"--after all, is there anyone who isn't already aware of the fundamentals of electrodiffusion? But this is really a minor trifle in an otherwise masterful work.
It's just a matter of time before Oprah gives this book a nod; buy it now and avoid the rush!
8 of 8 people found the following review helpful:
Keeps getting better with each Edition, 2002-03-26
This book is a must-have for anyone working with excitable cells, be they experimentalists or modelers. It's a great reference book; everything is clearly indexed and almost compulsively cited. I've been using this book since its first edition, and it just keeps getting better each time.
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